We must halt all ongoing Covid-19 mass vaccination campaigns as a temporary health benefit to the most vulnerable groups does not justify a public health disaster of international concern.
[I am] Geert Vanden Bossche, DVM, PhD virology, independent seasoned vaccine researcher, previous SPO at the Bill & Melinda Gates Foundation and SPM at GAVI is urging WHO and world political leaders to immediately halt all ongoing Covid-19 mass vaccination campaigns as there is compelling evidence that they will soon dramatically worsen the consequences of the current pandemic.
Attached to this letter, you will find a summary of the manuscript I am currently in the process of finalizing. I initially intended to attach the manuscript in full to my letter.
However, given the exceptional urgency of my call, I have no choice but to send you the summary (+ conclusion) in advance. I will post the manuscript in full on LinkedIn as soon as I can (presumably in the course of next week).
In the upcoming manuscript I will share my insights on the immune pathogenesis of Coronavirus pandemics. Those are based on an in-depth analysis of Covid-19-relevant scientific literature (key references will be appended) and backed by my deep vaccine knowledge and relentless perseverance in unraveling the host’s immune defense mechanisms and strategies viruses have evolved to escape those.
Understanding the interplay between the virus and the host immune system is a prerequisite for designing vaccines able to counter the immune subversive strategy of infectious pathogens.
I do not think that it is reasonable for WHO or any other health authority to approve ‘emergency use’ of vaccines aimed at conducting mass vaccination campaigns in the very heat of an infectious pandemic without having gained an in-depth understanding of how this may impact on the outcome of the pandemic.
In particular, lack of understanding of the consequences of immune pressure on highly mutable viruses has now allowed for the approval of a number of Covid-19 vaccines that are completely contraindicated for fighting a pandemic, regardless of the technology used.
Although safe and efficacious and providing temporary relief to part of the population and to healthcare facilities, these vaccines will soon come with a heavy toll to be paid by the entire population if mass vaccination campaigns continue.
Again, given the urgency of my call, I will neither allow time for peer-review, nor for English proofreading, nor for fine-tuning the wording or for screening the manuscript for redundancy.
As I merely seek to provide enough of compelling scientific proof for sounding this warning bell, I will not deal with relevant matters as exhaustively as I would normally do.
Clearly, the upcoming manuscript is not meant to be submitted to a scientific peer-reviewed journal but to explain the scientific rationale behind my cry of distress and urgent wake-up call.
May they for God’s sake draw the world’s attention to what I think is now likely to become the biggest and most tragic mistake made in the history of public health in general and in the field of vaccination in particular.
To support my wake-up call and credibility, I am not nearly as much relying on my credentials (which you can find at LinkedIn) as I am on a diversified set of relevant scientific reports from the literature and on the evolution of the pandemic itself. The latter is now featured by the emergence of much more infectious viral variants.
Nevertheless, you may still opt for now to not believe the statements, conclusions and forecasts that will be made in this manuscript and which have already been summarized as attached. However, I have no doubt that in the days and weeks to come ‘doubting Thomas’ will have to admit that he was proven wrong. In the meantime, these disastrous vaccination campaigns will likely be intensified and even extended to younger age groups.
Given the power, influence and blind ambition of the stakeholders driving these campaigns, it is going to be incredibly difficult to stop this act of complete madness. When all of them will finally have to admit the catastrophic consequences of this ‘experiment’, precious time and, more importantly, many more lives will have been lost. Eventually, complete lockdowns will likely be imposed for an undefinite period of time as a last resort.
Although largely based on direct or indirect scientific evidence, the views expressed in the manuscript will be my personal views. Of course, I take full accountability of what I am saying and I can only hope that those who’re in charge will be sufficiently convinced to take their responsibility and stop all ongoing Covid-19 vaccination campaigns immediately.
There should be no excuse and certainly no complaints about lack of warnings by dedicated experts. I cannot emphasize enough that continuing these vaccination endeavors will dramatically prolong, instead of shorten, the current pandemic and take a much higher toll in terms of disease and fatality rates in all of the population. It goes without saying that a such enhancement of this crisis will come with unbearable socio-economic consequences for many years to come.
The manuscript will provide compelling evidence that – as far as acute self-limiting viral infections are concerned – the natural course (i.e., without human intervention!) of a Coronavirus pandemic is typically featured by 3 waves that ultimately flatten as the infection merges into a seasonal ‘common cold.’
However, it is difficult to predict how long it would take a natural Covid-19 pandemic to ‘downgrade’ to yet another kind of seasonal ‘common cold’ without human intervention. Maybe somewhere between 2 to 4 years, but that’s a personal guess. This is, of course, not to say that in the meantime one should not do whatever is possible to mitigate the disease in those developing severe symptoms.
But first, “do no harm” (“primum non nocere”): Given the huge amount of immune escape that will be provoked my mass vaccination campaigns and flanking containment measures, it is difficult to imagine how human interventions would not cause the Covid-19 pandemic to turn into an incredible disaster for global and individual health.
I would have been able to put the appended manuscript together without having dedicated the last 10 years of my career to designing an entirely new vaccine concept that aims at enabling our immune system to kill a multitude of infectious (and even, noninfectious) diseases without allowing the pathogen, or any ‘variant’ editions thereof, to escape the immune response induced.
In contrast, all of the current Covid-19 vaccines rely on strengthening adaptive (as opposed to innate) immunity in general, and humoral (i.e. antibodies) in particular. Hence, none of them will prevent immune escape and, for that matter, all will be subject to anti-viral resistance. Adapting the composition to the new circulating variants does not solve the problem as science tells us that this will even accelerate the rate of immune escape (in asymptomatic Covid-19 carriers).
Isn’t it surprising that while we have now become so well aware of all dramatic consequences and threats surrounding microbial resistance to antibiotics, we still don’t believe that fighting viruses in ways that do not completely kill them opens the door to vaccine resistance?
While we have been taught to always take the medication for as long as prescribed, even if we were already feeling much better, we still don’t seem to believe that viruses can escape to specific antibodies if antibody concentrations or affinity are no longer sufficient to neutralize the virus.
Widespread use of antibiotics is generally acknowledged to raise a serious global concern about antimicrobial resistance, but nobody seems to bother about resistance to vaccines that are used in mass vaccination campaigns in the context of an ongoing pandemic. Since those are conducted against a huge infectious background, a multitude of vaccinees will be in the process of seroconverting while being exposed to circulating infectious virus.
Prophylactic vaccines against viral or other infectious diseases are typically administered well in advance of a likely risk of infectious exposure. While this is ensuring full-fledged protection to the infectious agent, it is also preventing immune escape and hence, resistance to the vaccine.
Aren’t we not already witnessing an increasing number of cases of Covid-19 vaccinated people who still shed virus and sometimes even develop mild symptoms? Aren’t these cases compelling enough in proving how easily Covid-19 viruses can escape antibody responses?
How can we then be so excited about current Covid- 19 vaccines knowing that they allow immune escape and thus, enable the virus to select more infectious variants? And do we really think that going for a one dose shot (instead of the prescribed 2-dose vaccination schedule), as some propose, is not going to even expedite immune escape?
In our naïve and simplistic attempt to prevent the pandemic from running its natural course, we are in fact providing the beast with an even much better opportunity to escape host immunity than natural infection does. The only way to do better than the natural pandemic is to eradicate Covid-19 right away.
To do so, there is probably no other way but to concentrate on vaccination strategies that allow DURABLE priming of innate immune killer cells (i.e., NK cells), the activation of which has already been shown to correlate with full viral clearance in asymptomatically Covid-19-infected subjects. As innate cytotoxic cells enable non-antigen-specific killing of the virus, they don’t drive immune escape.
By implementing immune intervention strategies that capitalize on empowering these innate immune cells to acquire immunologic memory, it must be possible to fully, broadly and durably protect human populations against all Covid-19 editions, and even against Coronaviruses at large.
The ‘sterilizing’ immunity they provide would not only protect people who would ‘naturally’ become asymptomatically infected (but, unfortunately, only enjoy natural protection for as long as they keep their innate immune system well-trained through moderate but regular pathogen exposure) but also subjects who would ‘naturally’ develop (severe) symptoms or even succumb to the disease.
In conclusion, fostering the development of NK cell-based vaccines should become a public health priority. As will become obvious from the manuscript, NK-cell based hold great promise for stopping this pandemic at its source while also ensuring future preparedness to emerging pandemic threats at large.
Author: Geert Vanden Bossche, DVM, PhD, 26 February 2021